Preventive method for periodontal disease by regulation of periostin

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670885
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Periodontology
• Research Institution: Hiroshima University
• Principal Investigator: KURIHARA HIDEMI 広島大学, 医歯薬保健学研究院, 教授 (40161765)
• Co-Investigator(Kenkyū-buntansha): UCHIDA Yuushi 広島大学, 医歯薬保健学研究院(歯), 助教 (40363080) ; FUJITA Tsuyoshi 広島大学, 病院, 講師 (80379883)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ペリオスチン / 歯肉上皮 / E-cadherin / アポトーシス / smad2 / TGF-beta

Outline of Final Research Achievements

Periostin suppresed the expression of E-cadherin in human gingival epithelial cells, suggesting that periostin down-regulate the barrier function of gingival epithelium. Since it has been reported that periostin secreted from epithelial cells activates TGF signaling, we examined the effect of TGF-beta on apoptosis of epithelial cells. The results showed TGF-beta induced mitochondria-dependent apoptosis in huma gingival epithelail cells. As apoptosis is known to induce the reduction of epithelail barrier, it may be suggested that TGF-beta/smad2 signaling and apoptosis are involved in the periostin-indueeced suppression of epithelial barrier.

Free Research Field

歯周病学