2014 Fiscal Year Final Research Report
Development of salivary aging marker that reflects the collagen metabolites
| Project/Area Number |
25670897
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Masahiro 慶應義塾大学, 先端研, 准教授 (30458963)
TANAKA Shoji 明海大学, 歯学部, 講師 (60105616)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | メタボローム解析 / グリシン / プロリン / 歯肉線維芽細胞 / 炎症 / 老化 |
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| Outline of Final Research Achievements |
The reason why salivary glycine and proline concentraions are increased during aging process, keeping the same ratio, was investigated. Three normal oral cells, such as human gingival fibroblast, periodontal ligament fibroblast and pulp cells produced these amino acids at 3 to 10 times lower speed, and have one order lower intracellular concentration as compared with glutamine and glutamic acid, under normal inflammatory and cytotoxic conditions. The intracellular concentration of proline was one third that of glycine. This suggests the possible enhancement of degradation of collagen and hydroxyproline.
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| Free Research Field |
薬理学
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