Reversing Aging: Regeneration of Aged Tissues using Adult Stem Cells Inside a Tissue exposed to Hydrogen Sulfide

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670898
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: Yaegaki Ken 日本歯科大学, 生命歯学部, 教授 (40166468)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 再生医療 / 若返り / 膵臓 / 肝臓 / β細胞 / インスリン

Outline of Final Research Achievements

This study had shown that hydrogen sulfide increases the number of b-cells and also insulin secretion from the cells reproduced from human tooth pulp. However high glucose decreased the number of cells and insulin secretion because of apoptosis. Hence we revised the protocol of regeneration of b-cells from human tooth pulp, and increased hydrogen sulfide concentration to 10 times, and glucotoxicities were almost disappeared, and the cells produced large amount of insulin. Thus exposing human tissue to hydrogen sulfide may cause reversing aging of the pancreas.

Free Research Field

口腔衛生