Designof clickable smart polymers for enrichment of biomarkers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25702029
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institute for Materials Science
• Principal Investigator: Mitsuhiro Ebara 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA准主任研究者 (10452393)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: スマートポリマー / バイオマーカー / 早期診断 / 温度応答性 / 感染症

Outline of Final Research Achievements

We have developed a series of nano-sized temperature-responsive polymer-protein conjugates that separate and enrich analytes from solution and enable detection. Because smart conjugates bind analytes in solution prior to separation, conjugate-analytes binding avoids steric and mass transport limitations associated with surface-based techniques. Thus, the “smart” polymer-based diagnostic systems could enrich dilute salivary samples, overcoming the problem of low power supply in the developing world while retaining the advantages of a rapid and reversible capture and concentration abilities.

Free Research Field

バイオマテリアル