Identification and development of therapeutic strategy for treatment of skeletal muscle loss and weakness "MYOPENIA"

2016 Fiscal Year Final Research Report

• Project/Area Number: 25702041
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Sports science
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Miyazaki Mitsunori 北海道医療大学, リハビリテーション科学部, 准教授 (20632467)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 運動生理学 / 骨格筋 / 悪液質 / マイオペニア / 細胞内シグナル伝達

Outline of Final Research Achievements

This research project was conducted to Identify and develop therapeutic strategies for treatment of skeletal muscle loss and weakness termed as "MYOPIA". Myopenia is generally developed under several physiological and pathological conditions including aging, hypomobility and wasting diseases such as AIDS/COPD/cancer.
Main achievements of this research project were summarized as follows. 1) Identification of intracellular signaling mechanisms regulating skeletal muscle size. 2) Comprehensive data analyses of gene expression in skeletal muscle under myopenic condition. 3) Development of the therapeutic interventions for myopenia using whole-body exercise.

Free Research Field

運動生理学