Underlying Mechanisms of Individual Difference in Age-related Arterial Stiffening

2016 Fiscal Year Final Research Report

• Project/Area Number: 25702045
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Applied health science
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Sugawara Jun 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00357261)
• Research Collaborator: MAEDA Seiji 筑波大学, 体育系, 教授
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 動脈硬化 / 心血管疾患リスク / 加齢 / 身体活動 / 遺伝子多型

Outline of Final Research Achievements

Arterial stiffness increases with age and becomes a strong risk for future cardiovascular disease. We determined underlying mechanisms of individual difference in age-related arterial stiffening from the view of genotype (e.g., polymorphism) and regular physical activity. We re-performed arterial stiffness measurement in 90 individuals (39 women, baseline age: 53±15 yrs) who engaged other experiments conducted in our laboratory approximately 10 years ago. Arterial stiffness increased by 12% in average, but individuals who had <15 METs/wk of regular aerobic exercise exhibited substantially smaller magnitude of age-related increase in arterial stiffness (+5.4%). This longitudinal investigation confirms the favorable effect of regular physical activity on age-related arterial stiffening. We are investigating the effect of interaction between genotype and regular physical activity.

Free Research Field

循環生理学