2014 Fiscal Year Final Research Report
Preparation of microhydrogel with hierarchic structures
| Project/Area Number |
25706010
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | マイクロ流路 / 組織工学 / 細胞足場 / セルロース |
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| Outline of Final Research Achievements |
This research describes a microfluidic device-based approach using a phase-separated polymer blend solution with rapid cross-linking process for fabrication of biomimetic bundle structured gel fibres as a candidate for cell culture scaffold that are able to mimic hierarchic tissue structures. As raw materials for bundled gel fibre, two natural derived biocompatible polysaccharide polymers are employed. The resulting bundled gel fibres are approximately 200 ~ 400 micrometer in diameter, consisting of 100 ~ 10000 aligned continuous microfibres, creating a composite fibrous material with enhanced mechanical properties which is a unique feature of three-dimensionally cross-linked multiple complex hierarchic fibres. As a result of cell culture study, the cells formed cylinder-like shape along the fibre orientation. We believe that these results promise to be a great candidate for tissue scaffolds but also wide biomaterial applications such as tissue engineering.
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| Free Research Field |
組織工学
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