2015 Fiscal Year Final Research Report
Develop bi-functional catalysts for innovative cross-coupling reaction
| Project/Area Number |
25708005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | カップリング反応 / 分子結合活性化 / 遷移金属触媒反応 / 天然物合成 |
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| Outline of Final Research Achievements |
The C-H coupling method (C-H/C-X type coupling) requires dramatic advantage compared with a classical cross-coupling method (C-M/C-X type coupling) from substrate scope, reactivity and utility the point of view. Meanwhile, the applicant have also already been reported C-H/C-O coupling of azoles with phenol/enol derivatives and decarbonylative C-H coupling of azoles with phenyl esters /alkenyl esters, that are formally enable to activate both C-H bond and relatively stable C-Y bonds (Y = OR, CO2R) at the same time. We believe that this kind of multi-bonds (ethers, esters, nitriles, and amides) functionalization to create C-C bonds is entirely different from classical cross-coupling method and is to be next-generation cross-coupling method as well as one of the molecular technologies. Based on the motivation, we developed such a coupling methods and an enabled catalysts. We have achieved rapid syntheses of useful molecules and natural products.
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| Free Research Field |
有機合成化学
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