2017 Fiscal Year Final Research Report
Studies on Alkylation Reactions of Arenes without Ortho-directing Groups
Project/Area Number |
25708006
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Organic chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2018-03-31
|
Keywords | ベンゼン / アルケン / アルキル化 / 遷移金属 / ニッケル / 協働触媒 / ルイス酸 / アルミニウム |
Outline of Final Research Achievements |
Alkylation reactions of arenes without ortho-directing groups have been investigated using alkenes as alkylating agents. First, we have found that nickel complexes bearing N-heterocyclic carbenes catalyze the reaction of benzene with 1-alkenes with unprecedentedly high linear selectivity to give linear alkylbenzenes. We have also shown that the nickel complexes in combination with aluminum-based Lewis acid cooperatively catalyze para- or meta-selective alkylation of benzenes bearing heteroatom-containing substituents such as aromatic carbonyl compounds, aromatic sulfonyl compounds, and anilides.
|
Free Research Field |
有機合成化学・有機金属化学
|