Sophisticate Design of Nano-Particular Type PET Probes for Qualitative Diagnosis and Theragnosis of Cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 25710011
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Mukai Hidefumi 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60570885)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: PETイメージング / がん / ナノ粒子 / セラグノーシス / 抗体 / ペプチド

Outline of Final Research Achievements

In vivo visualization of drug targets and disease-related molecules is essential for diagnosis and drug efficacy evaluation. To realize that, molecular probe development is a key. We developed novel approaches for the improvement of PET imaging contrast such as urokinase injection-triggered PET probe clearance enhancement system. These results could shorten the time required to obtain sufficient contrast and decrease patient radiation exposure.

Free Research Field

ドラッグデリバリー、分子イメージング