Live cell imaging-based estimation of information processing

2017 Fiscal Year Final Research Report

• Project/Area Number: 25710022
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: System genome science
• Research Institution: The University of Tokyo
• Principal Investigator: Sawai Satoshi 東京大学, 大学院総合文化研究科, 教授 (20500367)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: シグナル伝達 / 細胞運動 / 細胞性粘菌 / 定量的解析

Outline of Final Research Achievements

The project aimed at analyzing and understanding how extracellular signals of various spatio-temporal complexies are encoded at the level of signal transduction pathways. We employed Dictyostelium cell migration as a test case to quantitatively measure, based on live-cell confocal fluorescence imaging, the relationship between the spatio-temporal profiles of extracellular ligand versus several of the major signaling components that are important in determining their migratory behaviors. We found several key important properties such as fold-change dependency, adaptation, rectification in the input-output relations.

Free Research Field

細胞生物物理学