2016 Fiscal Year Final Research Report
Study on the splicing checkpoint mechanism to prevent pre-mRNA accumulation caused by splicing abnormality
| Project/Area Number |
25711001
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | University of Toyama |
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Principal Investigator |
Kaida Daisuke 富山大学, 大学院医学薬学研究部(医学), 准教授 (60415122)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | スプライシング / 転写 |
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| Outline of Final Research Achievements |
mRNA splicing is a fundamental mechanism for the gene expression in eukaryotes. Splicing abnormality might cause pre-mRNA accumulation and diseases. Therefore, I assumed that cells have a checkpoint mechanism that detects splicing abnormality and suppresses transcriptional elongation to prevent pre-mRNA accumulation. I revealed that such a splicing checkpoint mechanism actually exists in this study.
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| Free Research Field |
分子生物学
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