2016 Fiscal Year Final Research Report
Elucidation of mechanisms that regulate target recognition in selective autophagy
| Project/Area Number |
25711005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | オートファジー / リン酸化酵素 / タンパク質間相互作用 / 細胞内分解 / 膜輸送 |
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| Outline of Final Research Achievements |
Selective types of autophagy, which target and degrade specific components in cells, have recently attracted much attention due to their direct relations to a number of human diseases. In this study, using a budding yeast as a model organism, we analyzed how selective autophagy is controlled, and revealed that multiple selective autophagy pathways are regulated by a uniform mechanism. In addition, we discovered new selective autophagy pathways that target the nucleus and the endoplasmic reticulum, and elucidated their molecular basis. Results obtained in this study will serve as basic information in developing therapeutic methods for related diseases.
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| Free Research Field |
分子細胞生物学・生化学
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