2015 Fiscal Year Final Research Report
A molecular mechanism underlying cell orientation relative to global directional cues
| Project/Area Number |
25711013
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Akita University |
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Principal Investigator |
Yamazaki Masakazu 秋田大学, 医学(系)研究科(研究院), 准教授 (40373378)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 発生・分化 / 細胞・組織 / 遺伝学 / 平面内細胞極性 / PCP |
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| Outline of Final Research Achievements |
In Drosophila, planar cell polarity (PCP) molecules such as Dachsous (Ds) are thought to function as global directional cues orienting cellular asymmetry, which is manifested as polarized localization of PCP core proteins such as Frizzled (Fz). However, the relationship between the Ds gradient and Fz asymmetry in the eye is opposite to that in the wing, thereby causing controversy about how these two systems are connected. Here, using a combination of experiment and computer simulation, we elucidated a mechanism by which the Pk:Sple ratio determines the orientation of the core proteins relative to the Ds gradient.
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| Free Research Field |
発生生物学
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