2017 Fiscal Year Final Research Report
Molecular basis controlling the hierarchy of mouse spermatogenic stem cell populations
| Project/Area Number |
25711014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology (2016-2017)
Kyoto University (2013-2015) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | 幹細胞 / 精子 / 精巣 |
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| Outline of Final Research Achievements |
The mouse spermatogonial stem cell population is composed of two functionally distinct subpopulations and these subpopulations form hierarchal relationship. To reveal molecular basis controlling this hierarchy, we identified several genes specifically expressed in these populations from transcriptome analysis. Through the functional screening, we selected candidate genes and found one of the genes regulating transcriptional network to maintain undifferentiated state in cultured spermatogonial stem cells. We did not find the obvious phenotype in conditional knockout mice, and thus further analysis is needed to unveil the role.
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| Free Research Field |
発生生物学
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