2016 Fiscal Year Final Research Report
Observed regular protein aggregation structure and their fate, affecting the fail of our living organism homeostasis
| Project/Area Number |
25713012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Ryukoku University (2015-2016)
Kyoto University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | タンパク質凝集性疾患 / アンチトリプシン / ドメインスワップ |
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| Outline of Final Research Achievements |
In this study, we evaluate the toxicity of antitrypsin aggregates leading to disease in antitrypsin deficiency, which is represented by its lesion. We here consider the influence on the living body of the formation of an ordered aggregate structure of the causative protein. We examined that antitrypsin aggregates by three kinds of mechanisms and further clarified that its structure changes skillfully with time. Furthermore, due to the fact that they are also secreted out of the cell, abnormality of homeostasis in cells that may take in it was analyzed, but clear observation of cell death etc could not be obtained. Formation of regular aggregates of antitrypsin might be toxic to living organisms
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| Free Research Field |
構造生物学
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