Identification of Parkinson's disease genes and development of the personalized medicine

2016 Fiscal Year Final Research Report

• Project/Area Number: 25713015
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Human genetics
• Research Institution: Kobe University
• Principal Investigator: SATAKE Wataru 神戸大学, 医学(系)研究科(研究院), 助教 (50467594)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 神経遺伝 / パーキンソン病 / エクソーム / 個別化医療

Outline of Final Research Achievements

We performed a genome-wide association study (GWAS) of Parkinson's disease and reported four PD-risk genes previously. Here we performed a large scale exome-association study to identify rare variants with stronger effect size for the disease. We successfully identified fifteen nonsynonymous risk variants for Parkinson's disease.

Free Research Field

神経遺伝