2015 Fiscal Year Final Research Report
Construction of mass spectrometry based rapid cancer diagnosis system
| Project/Area Number |
25713023
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 機械学習 / バルクデータ / がん診断 / 大気圧イオン化法 / リアルタイム質量分析 / メタボロミクス |
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| Outline of Final Research Achievements |
We constructed the rapid diagnosis system for human renal cell carcinoma and hepatocellular carcinoma using probe electrospray ionization-mass spectrometry (PESI-MS) and learning machine, and achieved over 90% coincidence of diagnosis with those judged by the conventional histopathology. To validate the applicability of this system, we applied PESI-MS to diagnosis of various cancers. In this study duration, we could collect the 22,000 mass spectra from glioma, oral squamous cell carcinoma, gastric cancer, colonic cancer, bladder cancer, and pancreatic cancer.
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| Free Research Field |
細胞生物学
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