Crosstalk between sensory nervous system and immune system

2016 Fiscal Year Final Research Report

• Project/Area Number: 25713054
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Shinshu University
• Principal Investigator: SUGIYAMA Yuki 信州大学, 学術研究院医学系, 助教 (10468100)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 痛み関連受容体

Outline of Final Research Achievements

To investigate the relationship between sensory nervous system and immune system, we focused on TRPV1 which is known as very important multimodal nociceptor. In a mouse model of lipopolysaccharide (LPS)-induced peritonitis, mechanical hyperalgesia and activation of spinal sensory neurons were less in TRPV1 knockout (KO) mice compared to wild type (WT) mice, even though same degree of systemic inflammation occurred in both WT and TRPV1 KO mice. In late phase of LPS-induced peritonitis, marked splenomegaly was found in TRPV1 KO mice, although TRPV1 is not expressed or very little expressed on the surface of splenocytes. The number of splenocytes in TRPV1 KO mice was significantly increased compared to that in WT mice, and increased populations in the spleen were neutrophils, macrophages and CD4 T cells. These results clearly demonstrated that the difference of the pain sensation LPS-induced peritonitis regulates the immune system.

Free Research Field

麻酔科学