2016 Fiscal Year Final Research Report
New therapeutic strategies targeting lymphatic vessels for retinochoroidal disease
| Project/Area Number |
25713057
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 血管新生 / リンパ管新生 |
|---|
| Outline of Final Research Achievements |
Lymphatic vessels are known to be induced with angiogenesis in various diseases. We reported that typical lymphatic vessels were not induced in choroidal neovascularization which is often observed in age-related macular degeneration. In addition, macrophages are important for lymphangiogenesis. Our study revealed M2 macrophages are important in choroidal neovascularization. Furthermore, we reported M2 macrophages predominates with age, and that ROCK2 is the molecular target. Furthermore, we examined if lymphatic vessel could be induced during retinal neovascularization model, but Lyve-1 podoplanin positive lymphatics could not be observed. Lyve1 expression was elevated in the model and the expression could be observed in macrophages.
|
| Free Research Field |
血管生物学
|
