2016 Fiscal Year Final Research Report
Strategy to improve the quality of wound angiogenesis
| Project/Area Number |
25713059
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 血管 / 創傷治癒 / VEGF / VEGFR2 |
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| Outline of Final Research Achievements |
Once skin tissues are injured, the endogenous healing program takes place and damaged tissues are repaired or regenerated. Angiogenesis, formation of new blood vessels from nascent vessels, are believed to play a central role in this repairing process. However, the entity of the kinetics of blood vessels associated with wound healing is only ambiguously clarified. Here we established a new wound healing model using neonatal mice, suitable for visualizing the 3-D structure of blood vessels in wound tissues. Utilizing this technique, we found vascular changes during wound repair are mainly the vascular enlargement accompanied by increased blood flow, and the vessel curving caused by wound contraction, rather than typical angiogenesis. We also found the increase in diameter and blood flow depends on the VEGF-VEGFR2 signaling. These results suggest the vascular remodeling during wound healing is not a typical angiogenesis, but uniquely characterized as enlargement and curving.
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| Free Research Field |
血管生物学、形成外科学
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