Transcriptome of bacteria during host infection against autophagy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25713060
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Kyoto University (2014-2015); Tokyo Medical and Dental University (2013)
• Principal Investigator: Maruyama Fumito 京都大学, 医学(系)研究科(研究院), 准教授 (30423122)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: トランスクリプトーム / ゲノム / レンサ球菌 / オートファジー

Outline of Final Research Achievements

There are three major findings as follows: i) Streptococcus pyogenes are diversified into two subspecies using CRISPR by restriction of number and kind of phage invasion into genome, ii) One subspecies may appear by step-wise deletion of CRISPR and final complete deletion of CRISPR/cas system by an altruistic phage, iii) virulent type of this bacteria carries smaller genome size compared to the avirulent type, which is not related to phylogeny but related to specific SNPs that could determine the virulence.

Free Research Field

環境遺伝生態学