Identification and functional analysis of target microRNAs of angiogenesis factor regulating endochondral ossification

2016 Fiscal Year Final Research Report

• Project/Area Number: 25713064
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: FUJITA Yuko 九州歯科大学, 歯学部, 助教 (90514670)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: マイクロRNA / 血管新生 / 骨化 / マイクロアレイ / 咬筋 / 統合解析

Outline of Final Research Achievements

We performed microarray and integrated analyses of microRNA-mRNA expression profiles for masseter muscle in rats fed the soft or hard diets. In addition, we identified the miRNAs and mRNAs associated with the angiogenesis and endochondral ossification using Gene Ontology (GO) analysis.
GO analysis predicted interactions between 12 genes and 8 miRNAs, including some angiogenesis factors and ossification genes. In particular, 5 mRNAs associated with angiogenesis and endochondral ossification were identified as potential targets of rno-miR-19b-3p and rno-miR-181c-5p, respectively.

Free Research Field

小児歯科