2014 Fiscal Year Final Research Report
Modeling of genes and epigenome intracellular regulatory network and analysis of cellular differentiation mechanisms
Project/Area Number |
25730011
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Statistical science
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Research Institution | Tohoku University |
Principal Investigator |
KOJIMA Kaname 東北大学, 東北メディカル・メガバンク機構, 講師 (10646988)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 細胞内制御ネットワーク / エピジェネティクス / 次世代シークエンサー |
Outline of Final Research Achievements |
Regulatory networks comprised of only genes have been considered for the usual analysis of intracellular system. In the cell differentiation process, the alteration of epigenetic states such as DNA methylation and histone modification induces the change of regulatory structure and the change enables cells to be differentiated to other cells with difference functions. In this study, we devise new methods for estimating the abundance of gene expression, and methods for the foundation of highly accurate estimation of epigenetic states. Targeting the analysis of intracellular regulatory network, we devise the approach for estimating cell-specific transcription factor binding from gene expression data and histone modification data in the cell differentiation process of mouse.
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Free Research Field |
バイオインフォマティクス
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