Toward cytoskeleton-based understanding of neuronal morphogenesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25730177
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: Kyoto University
• Principal Investigator: Honda Naoki 京都大学, 医学(系)研究科(研究院), 准教授 (30515581)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 細胞骨格系 / アクチンフィラメント / 微小管 / 神経極性 / 成長円錐 / 糸状仮足

Outline of Final Research Achievements

We developed a mathematical model of elastic cytoskeleton. Based on this model, we identified the conditions that F-actins self-organize to bundle structure, mesh structure and network structure. We also developed a mathematical model of microtubule orientation in axon and dendrite, and then reproduced three distinct orientation patterns depending parameters. In addition, based on FERT imaging on migratory cells, we clarified how molecular signals are transmitted to morphological changes via cytoskeletal regulation. Moreover, we constructed a theory describing bi-directional attractive and repulsive turning response of the nerve growth cone.

Free Research Field

数理生物学