Analysisi of genetic instability induction by the introduction of non-DSB damages

2015 Fiscal Year Final Research Report

• Project/Area Number: 25740021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Osaka Prefecture University
• Principal Investigator: Urushibara Ayumi 大阪府立大学, 理学(系)研究科(研究院), 客員研究員 (80391275)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 非DSB型DNA損傷 / 紫外線 / 遺伝的不安定性 / 染色体異常 / 核型異常

Outline of Final Research Achievements

Ionizing radiation induces genetic instability in the progeny of the irradiated cells, that is estimated to be involved in radiation carcinogenesis. To clarify the mechanism of genetic instability is a very important because even lead to the elucidation of carcinogenic processes not only the biological effects of radiation. In this study, we hypothesized that some of the non-DSB type of DNA damage remaining after DSB repair may be related to the induction of genetic instability. As one of the causes that induce genetic instability, it was focused on the type of non-DSB damage. Then, we analyzed using delayed chromosomal aberrations and karyotype in order to clarify the differences in the genetic instability induced by the type of difference in damage.

Free Research Field

放射線生物学