Creation of a new method for assessing anti-obesity activity using 3T3-L1 adipocytes

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750048
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: UNNO Yuka 静岡県立大学, 薬学部, 助教 (30433212)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 肥満 / 炎症 / 脂肪細胞 / プロテアソーム / ヘテロクロマチン / 分化

Outline of Final Research Achievements

Being obese raises the risk of developing type 2 diabetes and other associated health problems. For treatment of obesity, a large reduction in caloric intake, along with increased physical activity, can produce a loss body weight over. But control caloric intake is not easy for us. In this study, I challenged to find new biomarker for ‘evaluation of anti-obesity activity’ using adipocyte. I found that several proteasome inhibitors have suppression effect of adipogenic differentiation in 3T3-L1 preadipocytes. Furthermore, one of proteasome inhibitors is selectivity towards immunoproteasome. These findings suggest that understanding roles of immunoproteasome in chronic local inflammation in adipose tissue is important for our study.

Free Research Field

分子細胞生物学