2014 Fiscal Year Final Research Report
Galanin-like peptide (GALP) has an anti-obesity effect and acts through the energy metabolism by autonomic nervous system.
| Project/Area Number |
25750053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 脂質代謝 / エネルギー代謝 / 神経ペプチド |
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| Outline of Final Research Achievements |
Galanin-like peptide (GALP), a 60-amino acid neuropeptide that was originally isolated from porcine hypothalamic extracts and is well known as a neuropeptide regulating feeding behavior and energy metabolism. In this study, I examined anti-obesity effect of GALP by focusing on lipid metabolism. In chronic infusion study, the body weight gain was decreased by GALP treatment as compared with the control group. The amount of lipid droplets was lower in the GALP group and hepatic triglyceride levels was decreased in the GALP groups compared with the vehicle group. Hepatic fatty acid oxidation-related gene mRNA levels were increased in the GALP group.The present study indicates that stimulates the hepatic lipid metabolism and anti-obese effect of GALP is evident with both central and intranasal administration.
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| Free Research Field |
生活科学
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