Effects of mineral deficiency diet on between aging-disease and reactive oxygen signal

2015 Fiscal Year Final Research Report

• Project/Area Number: 25750057
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: Inoue Hirofumi 東京農業大学, 応用生物科学部, 助教 (10639305)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 鉄欠乏 / オートファジー / 酸化ストレス

Outline of Final Research Achievements

This study investigated the effects of iron deficiency diet on inflammation and senescence in vivo and in vitro. (1)We investigated the effects of dietary iron deficiency on the redox system in young or old mice. Dietary iron deficiency increased accumulation of carbonylated proteins and expression levels of an antioxidant enzymes and an autophagic marker compared to control diet. (2)Iron-specific chelator induce protein aggregation by increasing gene expression of p47phox. In addition, DFO treatment upregulated the expression of the autophagic genes during autophagy and anti-oxidant enzymes. Furthermore, DFO treatment also increased senescence-related molecules. These results suggested that anti-oxidant systems and autophagy in iron deficient condition protects from oxidative stress.

Free Research Field

食生活