Effect of sesame and the sesame lignane intake on vitamin E concentration and oxidation stress.

2017 Fiscal Year Final Research Report

• Project/Area Number: 25750060
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Aichi Gakusen University
• Principal Investigator: Uchida Tomono 愛知学泉大学, 家政学部, 准教授 (50440821)
• Research Collaborator: IKEDA SAIKO 名古屋学芸大学, 管理栄養学部, 教授 ; SUZUKI NORIE 名古屋学芸大学, 管理栄養学部, 助手 ; エーザイフード・ケミカル株式会社
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: ビタミンE / γ-トコフェロール / ゴマリグナン / セサミン

Outline of Final Research Achievements

Inhibition of lipoprotein lipase in rats, the effect of sesamin to increase vitamin E concentration was investigated.Serum and small intestinal γT concentrations increased due to ingestion of γT (one type of vitamin E) and sesamin, but the metabolite of γT (γ-CEHC) decreased.Therefore, sesamin inhibits γT metabolism in the small intestine,and Sesamin was supposed to promote γT absorption.Furthermore, when healthy people ingest sesame and γT, urinary metabolites(γ-CEHC) excretion decreases. The plasma γT concentration also tended to increase.Therefore, we concluded that inhibition of vitamin E metabolism by sesamin ingestion is also seen in humans.We expected antioxidant lipid suppression effect due to elevation of vitamin E concentration in the body,but this time it was not confirmed.

Free Research Field

栄養学