Development of cell-vibration microdevice wiht piezoelectric thin film

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750158
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Toyohashi University of Technology
• Principal Investigator: KAWASHIMA Takahiro 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (50378270)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 細胞機能制御 / 機械的振動刺激 / 圧電アクチュエータ / BioMEMS

Outline of Final Research Achievements

In this study, we have been developing a cell-vibration microdevice with piezoelectric thin film for screening and optimization of the influencing factors of mechanical vibratory stimuli to cells. The microdevice was fabricated by the proposed fabrication process. Moreover, a cell arrangement method using dielectrophoresis was adopted to trap cells on the microdevice. The study revealed that the method was effective to trap cells. Finally, cell culture experiments were executed in order to evaluate cell adhesion on substrates. As a result, it was found that the surface material of the microdevice was important to cell behavior.

Free Research Field

BioMEMS