2014 Fiscal Year Final Research Report
Development of fluorine-19 MRI probes to evaluate pathological features in Alzheimers disease
| Project/Area Number |
25750159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アルツハイマー病 / フッ素MRI / 老人斑 / 神経原線維変化 |
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| Outline of Final Research Achievements |
Fluorine-19 magnetic resonance imaging (19F MRI) could be a promising approach for imaging amyloid deposition in the brain. However, the required features of a 19F MRI probe for amyloid detection remain unclear. In the present study, we investigated a series of compounds as potent 19F probes that could prevent the reduction in MR signal when bound to amyloid plaques in the brain. We found that 6-(3’,6’,9’,15’,18’,21’-heptaoxa-23’,23’,23’-trifluorotricosanyloxy)-2-(4’-dimethylaminostyryl)benzoxazole (Shiga-X22), which has a trifluoroethoxy group with seven ethylene glycol groups in the PEG chain, showed significant 19F MR signals in the brains of APPswe/PS1dE9 double-transgenic mice, but not wild-type mice. This suggested that Shiga-X22 could be a useful 19F MRI probe for amyloid detection. Furthermore, we synthesized new probes for neurofibrillary tangles, which has a trifluoroethoxy group with different number of ethylene glycol groups in the PEG chain.
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| Free Research Field |
生体医工学・生体材料学
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