2015 Fiscal Year Final Research Report
Regulation of neuroinflammation by low-reactive level laser irradiation
Project/Area Number |
25750169
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Yamato Masanori 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (50565778)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 近赤外レーザー / 脳内神経炎症 / エネルギー代謝 |
Outline of Final Research Achievements |
Low-level laser therapy (LLLT) has recently been used as a new anti-inflammatory clinical therapy and is associated with few, if any, side effects. In the present study, we clarified that externally directed LLLT could penetrate into brain and that LLLT slightly suppressed the expressions of inflammatory cytokines in rat brain. Next, metabolome analysis of brain showed that the changes in many metabolites related to energy production or neurotransmission were observed. Now we focus on the effect of LLLT on change of energy metabolism in the brain during neuroinflammation.
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Free Research Field |
神経科学
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