Fabrication of self-assembled nanoparticles using homo/hetero-stereocomplex formation of poly(lactide)

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: AKAGI Takami 大阪大学, 臨床医工学融合研究教育センター, 特任研究員(常勤) (00527236)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ナノ粒子 / ポリ乳酸 / ステレオコンプレックス / ドラッグデリバリーシステム / ワクチン

Outline of Final Research Achievements

Self-assembled nanoparticles (NPs) composed of poly(γ-glutamic acid) (γ-PGA) as a hydrophilic backbone and enantiomeric poly(lactide) (PLA) as a hydrophobic side chain were prepared using stereocomplex (SC) formation of PLA. The γ-PGA-PLA SC NPs exhibit a lower critical aggregation concentration (CAC) as well as stronger kinetic stability compared with the corresponding isomer NPs. Moreover, mouse immunization with ovalbumin (OVA)-encapsulated SC NPs　predominantly induced OVA-specific cellular immunity. The findings suggest that the γ-PGA-PLA SC NPs are suitable for protein-based vaccines that are used to induce cellular immunity, such as for infectious diseases, cancer, allergies and autoimmune diseases.

Free Research Field

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