Fabrication of Fragmented Nanosheets with Patchwork-adhesion Behavior and Their Biomedical Applications

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750178
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokai University
• Principal Investigator: OKAMURA Yosuke 東海大学, 創造科学技術研究機構, 講師 (40365408)
• Research Collaborator: INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548) ; SUMIYOSHI Hideaki 東海大学, 医学部, 講師 (60343357) ; TAKANO Shuta
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ナノ材料 / 超薄膜

Outline of Final Research Achievements

We have proposed biodegradable ultra-thin films, so-called nanosheets. These nanosheets represent unique properties such as high flexibility and good adhesiveness. However, they are often hard to wrap irregular/uneven interfaces due to the structural aspect (cm-size). In this study, we proposeed a fragmentation method of the nanosheets composed of poly(L-lactic acid) (PLLA) and a patchwork coating against various interfaces.
The PLLA nanosheets could be easily fragmented by homogenization and then reconstructed into a sheet on various interfaces without any adhesive reagents. We refer to this reconstruction as a “patchwork” technique. For a biomedical application, we demonstrated that the patchwork of fragmented nanosheets act as an anti-tissue adhesion materials.

Free Research Field

生体材料学