Compared the effects of exercise induced hypoalgesia on endogenous pain modulatory mechanisms in chronic pain patient vs healthy control

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750232
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya Gakuin University
• Principal Investigator: SHIRO Yukiko 名古屋学院大学, リハビリテーション学部, 講師 (30440663)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 運動 / 鎮痛 / 自律神経 / 脳波 / 慢性痛

Outline of Final Research Achievements

Changes in mechanical sensitivity can occur in response to exercise in healthy subjects and may involve multiple interacting peripheral and central pain-modulatory mechanisms. In contrast, the experimental pain rating of patients with chronic pain increased after exercise, thereby suggesting abnormal pain modulation. We aimed to investigate the effect of exercise-induced hypoalgesia (EIH) using electroencephalography and sympathetic nerve activity in patients with chronic pain compared with that in healthy controls. The effect of EIH depended on the level of attention demand and sympathetic nerve activity during exercise. However, EIH and sympathetic nerve activity to the exercise decreased in patients with chronic pain. Therefore, abnormal sympathetic nerve activity could be factor of chronic pain.

Free Research Field

痛み学