Molecular mechanisms underlying exercise training-induced metabolic memory in skeletal muscle

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: The University of Tokyo
• Principal Investigator: TERADA Shin 東京大学, 総合文化研究科, 准教授 (00460048)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 骨格筋 / 糖代謝 / 糖輸送体GLUT-4 / ヒストン / トレーニング

Outline of Final Research Achievements

Endurance exercise training induced glucose transporter GLUT-4 biogenesis in skeletal muscle, leading to improved whole-body insulin sensitivity. The purpose of this study was to examine the hypothesis that individuals with a history of previous endurance training can easily acquire the metabolic adaptation in skeletal muscle on retraining. This study showed that in rat skeletal muscle that had experienced endurance exercise training, GLUT-4 gene was upregulated rapidly in response to acute bout of exercise after detraining. These results suggest that effects of previous endurance exercise training can be retained as “metabolic memory” or “muscle memory”. The results observed in this study also suggest that histone hyperacetylation may not be involved in the endurance exercise training-induced metabolic memory in skeletal muscle.

Free Research Field

運動生理・生化学