Analysis of relationships between the changing amount of skatole, an enterobacterium-derived dietary protein metabolite, and liver functions.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25750356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Hokkaido University
• Principal Investigator: SHIMIZU Hidehisa 北海道大学, (連合)農学研究科(研究院), 特任講師 (10547532)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: スカトール / 回腸 / タウロコール酸 / 抱合型胆汁酸 / デオキシコール酸 / 二次胆汁酸 / 動物性タンパク質 / 腸内細菌代謝物

Outline of Final Research Achievements

In the present study, we analyzed the effect of skatole on the liver functions. Male SD rats were fed a diet supplemented with or without skatole for 28 days. The ingestion of skatole modulated bile acid metabolism, which is mainly regulated in the liver. However, inflammatory response may be not initiated during this ingestion period because the expression level of TNF alpha, one of the inflammatory cytokine genes, in the liver, ileum, and colon was not changed between control and the Skatole-fed rats. Furthermore, the present study also examined whether modulated bile acid metabolism influences the initiation and progression of atherosclerosis. Deoxycholic acid, a representative secondary bile acid, enhanced proliferation and migration of vascular smooth muscle cells. Taken together, it is possible that change of bile acid metabolism by increased skatole concentration in gastrointestinal tract is involved in the pathogenesis of atherosclerosis.

Free Research Field

病態生理学