2014 Fiscal Year Final Research Report
Role of reactive oxygen species and antioxidant enzymes in cellular iron metabolism
| Project/Area Number |
25750367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 酸化ストレス / 鉄代謝 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the relationship between reactive oxygen species (ROS) and iron metabolism in age-related disturbance of iron metabolism. It was shown that the 2,3-Dimethoxy-1,4-naphtoquinone (DMNQ), a superoxide generator, and ammonium tetrathiomolybdate (TTMo), an inhibitor of superoxide dismutase, induced the phosphorylation of iron regulatory protein 1 (IRP1) via protein kinase C (PKC) activation. In addition, treatment with 4-hydroxy-s-nonenal (4-HNE), an end products of lipid peroxidation, inhibited IRP1 activity and caused a decrease in expression of iron transporters. These results suggest that ROS control iron metabolism through IRP1 regulation.
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| Free Research Field |
複合領域
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