The role of taurine-sensing mechanism by the aging-related signaling pathway on sarcopenia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25750368
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Hyogo University of Health Sciences
• Principal Investigator: Ito Takashi 兵庫医療大学, 薬学部, 講師 (80423119)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: サルコペニア / 筋肉 / タウリン

Outline of Final Research Achievements

It has been reported that tissue taurine depletion accelerates skeletal muscle aging accompanied with enhancement of the phosphorylation of ribosomal protein S6 subunit (RPS6), which is a downstream target of mTOR, an aging-related signal protein. In the present study, we investigated the signaling pathway involved in RPS6 phosphorylation to reveal the mechanism of aging acceleration. We identified that signaling pathway responsible for unfolded protein response are activated in taurine-depleted mouse, suggesting the accumulation of endoplasmic reticulum stress by tissue taurine depletion. Moreover, we found that endoplasmic reticulum stress induces the phosphorylation of RPS6 in skeletal muscle cells. These results suggest that taurine depletion causes RPS6 phosphorylation through ER stress accumulation and then accelerates skeletal muscle aging.

Free Research Field

薬理系薬学