Synthesis and regulation of the phosphorylated signal in vivo template assisted synthesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25750394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: Osaka University
• Principal Investigator: Manabe Yoshiyuki 大阪大学, 理学(系)研究科(研究院), 助教 (00632093)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: TGF-β / 翻訳後修飾糖鎖 / コアフコース / 動的コンビナトリアルケミストリー / FUT8

Outline of Final Research Achievements

Transforming growth factor-β (TGF-β) regulate various kinds of biological phenomena, such as cell growth, apoptosis and so on. The purpose of this study is developing the novel method to regulate this signal. We developed the phosphorylated Smad2 recognition peptide using dynamic combinatorial chemistry. We also investigated the regulation of TGF-β signal by controlling the function of translational modification sugar on TGF receptor. For this purpose we developed the molecule which bind to core fucose and which inhibit the formation of core fucose.

Free Research Field

ケミカルバイオロジー