2015 Fiscal Year Final Research Report
Investigation of network-level effect after perturbation of eye movement related cortical areas through optogenetics and fMRI in macaques
| Project/Area Number |
25750399
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Niigata University (2014-2015)
The University of Tokyo (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | マカクザル / 機能的核磁気共鳴画像法 / 大脳皮質不活性化 / functional connectivity |
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| Outline of Final Research Achievements |
The cerebral cortex is a functional network consisting of a vast number of long-range interactions between brain areas, and the influence at the level of this global network in consequence of local cortical inactivation remains unclear. We reversibly inactivated the macaque prearcuate cortex during functional magnetic resonance imaging experiments and detected the global influence on the network of functional connectivity (FC) between cortical areas across the whole brain. Our results showed that quantitative relations exist between the changes in FC between distant areas and the FC between the inactivated site and these areas in the no-inactivation condition, even in area pairs remote from the inactivated site.
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| Free Research Field |
認知神経科学
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