2014 Fiscal Year Final Research Report
Development of pulmonary surfactant preparations incorprated by fluorinated materials
| Project/Area Number |
25790020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Osamu 長崎国際大学, 薬学部薬学科, 教授 (10117129)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ナノ機能材料 / ナノ医薬 / 肺サーファクタント / 複合材料 |
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| Outline of Final Research Achievements |
Our objective is to develop cheap, safe, and effective artificial pulmonary surfactant preparations. Our attention was here paid on "cheapness" for the production cost of the preparations. The main component of the natural pulmonary surfactants is dipalmitoylphosphatidylcholine (DPPC) and thus we try to substitute with phospholipids derived from an egg yolk and a soybean. First, we made lots of artificial preparations model peptide (Hel 13-5) and their interfactial properties have been investigated thoroughly. As a result, some preparations were possible to be produced at the cheaper cost than Surfacten and also they indicated the effect at the same level as Surfacten. We intend to examine the pulmonary surfactactant preparations by incorporation of fluorinated componds which have high oxygen dissolution ability and very chemical stablization to get the further efficacy.
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| Free Research Field |
界面化学
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