Multi-scale modeling of blood cell membrane and clarification of adhesion phenomenon

2015 Fiscal Year Final Research Report

• Project/Area Number: 25790097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Computational science
• Research Institution: Osaka University
• Principal Investigator: Ii Satoshi 大阪大学, 基礎工学研究科, 助教 (50513016)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 血球 / マルチフィジックス / 連成解析 / 二層膜 / 半透膜 / 浸透圧 / 接着力推定

Outline of Final Research Achievements

In this study, in order to reveal dynamic behaviors of blood cell in adhesion and high shear flow, we have proposed: 1) two-layer membrane model including slipping between lipid bilayer and spectrin network phase; 2) formulation for osmotic swelling and shrinking of a capsule with a semi-permeable membrane; 3) inverse analysis model for evaluation of adhesion force in an experiment. We have uncovered that, in high shear flow, slipping velocity apparently and locally appears on the membrane, and local difference of the membrane force affects the osmotic behavior of the blood cell. Moreover, we have showed a feasibility of the inverse analysis of adhesion force evaluation in experiments that includes a three deformation field.

Free Research Field

計算力学，バイオメカニクス，数値流体力学