Creation of crystalline nanocavities based on peptide folding

2014 Fiscal Year Final Research Report

• Project/Area Number: 25810046
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional solid state chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: SAWADA Tomohisa 東京大学, 工学(系)研究科(研究院), 助教 (70625467)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 自己組織化 / 結晶材料 / ペプチド / 配位結合 / 分子認識 / ナノ空間 / フォールディング

Outline of Final Research Achievements

In this work, a new artificial peptide-based nanomaterial was created by the strategy of coordination-driven self-assembly with concomitant folding and assembly processes. A tripeptide with coordinating groups at both termini was designed and successfully complexed with silver(I) ion to give a crystalline porous material. The nanochannel of this material was composed of polyproline II helix of the peptide ligand and its diameter reached more than 2-nm-size. Furthermore, unique molecular recognition properties of this new material were also revealed.

Free Research Field

超分子化学