Probing the mechanism and application of NMR chiral sensing based on achiral molecules

2014 Fiscal Year Final Research Report

• Project/Area Number: 25810055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional solid state chemistry
• Research Institution: National Institute for Materials Science
• Principal Investigator: ISHIHARA Shinsuke 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, NIMSポスドク研究員 (30644067)
• Co-Investigator(Renkei-kenkyūsha): LABUTA Jan 独立行政法人物質・材料研究機構, 若手国際センター, ICYS研究員 (00720690) ; HILL Jonathan 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA Scientist (30421431)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: キラル / 不斉認識 / NMR / 分子認識 / センサー

Outline of Final Research Achievements

We have developed a oxoporphyrinogen derivative, which can be available as NMR chiral solvating agent of various chiral molecules. NMR split of oxoporphyrinogen has linear relationship between enantiomeric excess % of chiral molecules. Based on theoretical calculations, we proved that chiral sensing is based on magnetic anisotropy induced by chiral molecule, and also average of the anisotropy upon fast exchange equilibrium.

Free Research Field

超分子