Catalyst Design Based on a Multi-Point Immobilization Strategy for Practical Organic Synthesis with Non-Platinum Group Metals

2015 Fiscal Year Final Research Report

• Project/Area Number: 25810056
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Iwai Tomohiro 北海道大学, 理学(系)研究科(研究院), 助教 (30610729)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 不均一系触媒 / 非白金属元素 / ホスフィン / 遷移金属触媒 / クロスカップリング / ポリスチレン / シリカゲル

Outline of Final Research Achievements

The researcher worked on the development of highly active catalysts for practical organic synthesis with non-platinum group metals on the basis of an independently developed multi-point immobilization strategy. A newly prepared polystyrene-cross-linking bisphosphine PS-DPPBz containing a 1,2-bis(diphenylphosphino)benzene core was found to be an effective ligand for the Ni-catalyzed amination of aryl chlorides with N-alkyl-substituted primary amines, the Ni-catalyzed C-H/C-O coupling between 1,3-azoles and aryl pivalates, and the Co-catalyzed alkene hydroboration. During this study, it was found that solid-supported monophosphines with mono-P-ligating properties enabled the heteroatom-directed Ir-catalyzed C(sp3)-H borylation and the Pd-catalyzed cross-coupling of aryl chlorides.

Free Research Field

合成化学