Studies on iron-catalyzed cross-coupling via intramolecular cyclization and allylic substitution reaction

2014 Fiscal Year Final Research Report

• Project/Area Number: 25810064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Kochi University
• Principal Investigator: NAGANO TAKASHI 高知大学, 教育研究部自然科学系, 助教 (80500587)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 鉄触媒 / クロスカップリング / アリル位置換反応 / グリーンケミストリー

Outline of Final Research Achievements

As a part of our continuing studies on environmentally benign organic transformations, we have focused on inexpensive and abundant iron salt-catalyzed carbon-carbon bond forming reactions. In the course of this study, we have developed (i) iron-catalyzed Grignard cross-coupling via intramolecular cyclization, (ii) iron-catalyzed Grignard cross-coupling with allylic ethers (allylic substitution), and (iii) unprecedented cross-coupling of hard nucleophiles with 2-bromo-1,3-dienes giving corresponding substituted allenes.

Free Research Field

有機合成化学