2016 Fiscal Year Final Research Report
Development of cancer and Alzheimer's disease diagnostic methods by fluorescence monitaring repeat structures
| Project/Area Number |
25810090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
Itoyama Miki 福岡大学, 薬学部, 助教 (60549690)
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| Research Collaborator |
NOHTA Hitoshi
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 蛍光モニタリング / 繰り返し構造 / ピレン試薬 |
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| Outline of Final Research Achievements |
For diagnosis of cancer and Alzheimer's disease, some analytical methods were developed to monitor the length of telomere repeat, the accumulation of tau protein and the phosphorylation of amyloid beta-protein.
In this study, the new optimal fluorescent reagent was designed and synthesized for biological samples. The cation label type reagent we synthesized is stable, easy to solve in hydrophilic solvent, and does not need high temperature heating.
Furthermore, the new analytical methods, for polyamines, amino acids, nucleotides and some peptides, were developed using fluorous separation technique.
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| Free Research Field |
分析化学
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