Development of Biocompatible Platinum Nanoclusters as Fluorescence and Electron Microscopic Imaging Probes and Application to Biomedical Imaging

2014 Fiscal Year Final Research Report

• Project/Area Number: 25810100
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: Kure National College of Technology
• Principal Investigator: TANAKA Shin-ichi 呉工業高等専門学校, 自然科学系分野, 准教授 (30455357)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 光化学 / 生物物理学 / 蛍光観察 / １分子計測 / 分子プローブ / 白金ナノクラスター / 生体イメージング / 癌診断

Outline of Final Research Achievements

Noble-metal (gold (Au), silver (Ag) and platinum (Pt)) nanoclusters consisting of several atoms have been applied for advanced biological application in sensing, cellular imaging, and biomedicine owing to their excellent physicochemical properties and biocompatibility, such as smaller size, less cytotoxicity, tunable fluorescence emission and high photostability. In this study, we have developed the biocompatible Pt nanoclusters as fluorescence and electron microscopic imaging probes, and have applied them to in vitro and in vivo imaging. Since the Pt nanoclusters are less cytotoxic as well as smaller than other nanoparticles such as quantum dots and carbon nanotubes, the fluorescent Pt nanoclusters promises to be a useful fluorescent probes for bio-imaging and long-term in vivo imaging.

Free Research Field

光化学